By Jan P. A. Baak M.D., Ph.D., Jan Oort M.D., Ph.D. (auth.)

ISBN-10: 3642748236

ISBN-13: 9783642748233

ISBN-10: 3642748252

ISBN-13: 9783642748257

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Extra info for A Manual of Morphometry in Diagnostic Pathology

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Prognostic indicators in breast cancer - morphometric methods. Histopathology 6, 327-339. , With, C. de (1977). Discriminant analysis exemplified with quantitative features of the endometrium. Eur. J. Obstet. Gynec. Reprod. BioI. 8: 209-215. , Kaam H. , Leach, A. P A. (1982a). Morphometry and cytodiagnosis of breast lesions. Virchows Arch. (PathoI. ) 369, 9-18. J. A. {1982b}. Computation of pre-operative diagnosis probability for follicular adenoma and carcinoma of the thyroid on aspiration smears.

In this decision tree three diagnostic decision steps are available (invasive growth; multilayering more than three cells deep; presence of severe atypia). Each step of the decision tree consists of a block, in which the outcome of the decision indicates a certain diagnostic direction. The decisions are taken se- quentially. 31 Mucinous ovarian tumour no Take other samples yes Select area with highest tumour grade yes Malignant tumour yes Borderline tumour Fig. 4. A more complex decision tree (after Hart and Norris, 1973)..

Absence of nuclear membrane 2. Absence of clear zone in centre 3. Presence of hairy instead of triangular or spiky projections 4. Basophilia of surrounding cytoplasm instead of eosinophilia Thus, the following measures must be taken when counting mitotic figures (Kempson, 1976; Norris, 1976): 19 1. 1m in thickness. 2. Adequate sampling: mitotic figures should be counted in those areas where their number is highest. As there may be considerable differences from one place to another, at least 10 sections per borderline tumour, or one section for each centimetre of diameter of the tumour should be taken, whichever is greater.

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A Manual of Morphometry in Diagnostic Pathology by Jan P. A. Baak M.D., Ph.D., Jan Oort M.D., Ph.D. (auth.)

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