By Sudarshan K. Malhotra
A part of a chain which goals to hide fresh wisdom within the box of neural technological know-how, this quantity discusses such subject matters as: the molecular bases of nerve regeneration; plasticity of descending spinal pathways in constructing mammals; and improvement of the mammalian auditory hindbrain.
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Additional info for Advances in Neural Science, Volume 2 (Advances in Neural Science)
V. NEUROREGULATORY MECHANISMS A. Interactions Between Neuropeptide Systems Colocalization of Neuropeptides and Neurotransmitters Somatostatin. , 1977). , 1983; see references in Epelbaum, 1986). The majority of cortical SRIF-positive neurons found in layers II-III and V-VI are also glutamic acid decarboxylase (GAD) positive. In the hippocampus they are located in the stratum oriens and in the hilus of the dentate gyrus. In contrast, SRIF and Ach do not appear to be colocalized in the CNS (Eckenstein and Baughman, 1984; Vincent and Johansson, 1983).
1990; Kentroti and Vernadakis, 1995). , 1991). It appears that the most prominent labeling of astrocytes is in (1) large subependymal glia in the ventricular wall, particularly in a position that corresponds to that of SRIF-producing perikarya and (2) perivascular astrocytes in the same regions. The significance of SRIF receptors on astrocytes is a matter of speculation. , 1991) that astrocytes may be involved in the removal of the peptide from the intercellular cleft or the target cell; on the other hand, glial cells may be the primary target of SRIF.
Although the research on the ontogeny of neuropeptide receptors is not extensive, the decline in receptor binding sites from development to adulthood is further supportive evidence that neuropeptides have neuromodulatory actions during early neuroembryogenesis. Finally, recent research attempting to explore the neuromodulatory actions of neuropeptides during early brain development clearly demonstrates that neuropeptides are actively involved in (a) neuro- Neuropeptides in Development 37 nal homeostatic balance via their influence on neuronal survival and (b) the establishment of neuronal phenotypes by influencing neuronal plasticity during early neuronal differentiation.
Advances in Neural Science, Volume 2 (Advances in Neural Science) by Sudarshan K. Malhotra