By Alexandra Columbus

ISBN-10: 160021150X

ISBN-13: 9781600211508

ISBN-10: 1608762300

ISBN-13: 9781608762309

"Advances in Psychology examine" offers unique effects at the innovative of psychology. each one article has been conscientiously chosen in an try and current colossal study effects throughout a wide spectrum.

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Additional info for Advances in Psychology Research Volume 44

Sample text

Twenty-seven studies were meta-analyzed, including 803 depressed patients. The majority of randomized controlled trials has demonstrated substantial efficacy of lithium augmentation in partial and non-responders to antidepressant treatment. In the placebo controlled trial, the mean response rate in the lithium group was 45% and in the placebo group 17%. Approximately 50% of patients responded to lithium augmentation within 4 weeks. The results of this analysis suggest that lithium addition is still most well-documented augmentation strategy in refractory depression.

Cell 2001, 105, 769-779. [53] Melia PI. Prophylactic lithium: a double-blind trial in recurrent affective disorders. Br J Psychiatry 1970; 116: 621-624. [54] Mendels J. Lithium in the treatment of depression. Am. J. Psychiatry 1976, 133, 373378. [55] Moncrieff J. Lithium: evidence reconsidered. Br J Psychiatry 1997, 171, 113-119. [56] Moore GJ, Bebchuk JM, Wilds IB, Chen G, Manji HK. Lithium-induced increase in human brain grey matter. Lancet 2000, 356, 1241-1242. [57] Müller-Oerlinghausen B, Müser-Causemann B, Volk J.

It was not until several decades later that John Cade, Australian psychiatrist working in Melbourne, performed experiments aiming to explain a possible pathogenic role of uric acid in mania. He found that the urine from manic patients was particularly toxic to guinea pigs. When the pigs were given lithium urate, they showed significantly less symptoms of toxicity and were significantly calmed. g. lithium carbonate. As a next step, Cade made himself volunteer and took several doses of lithium carbonate himself without observing any harmful effect.

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Advances in Psychology Research Volume 44 by Alexandra Columbus


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