By Ioannis Papaioannou, James S. Owen (auth.), David Abraham, Handler Clive, Michael Dashwood, Gerry Coghlan (eds.)

ISBN-10: 1848826362

ISBN-13: 9781848826366

Understanding the various advanced mobile and molecular mechanisms underlying human vascular ailments is key in bettering the administration of sufferers with this clinically very important and wide-ranging staff of ailments. this can be rather very important while contemplating the level of this factor around the world.

Written by means of a crew of world-renowned experts, Advances in Vascular Medicine highlights the various relationships among simple technology and medical drugs, and studies either learn and scientific perform tools and results in vascular biology and pathobiology. it's an authoritative reference for those very important issues of vascular biology and comprises chapters that designate the scientific matters to the fundamental scientist in addition to offering clinicians with a systematic grounding in vascular illnesses. even though there's nonetheless a lot paintings to be performed to improve knowing of vascular illness, the knowledge and insights contained during this publication are a necessary contribution to the literature, giving scientists and clinicians the chance to profit extra approximately this intriguing box of biomedicine.

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5. Rader DJ. Molecular regulation of HDL metabolism and function: implications for novel therapies. J Clin Invest. 2006;116:3090–3100. 6. Rye KA, Barter PJ. Formation and metabolism of prebeta-migrating, lipid-poor apolipoprotein A-I. Arterioscler Thromb Vasc Biol. 2004;24:421–428. 7. Lusis AJ. Atherosclerosis. Nature. 2000;407:233–241. 8. Fisher EA, Ginsberg HN. Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteins. J Biol Chem. 2002;277:17377–17380.

2004;432:173–178. 34. Zimmermann TS, Lee AC, Akinc A, et al. RNAi-mediated gene silencing in non-human primates. Nature. 2006;441:111–114. 35. Frank-Kamenetsky M, Grefhorst A, Anderson NN, et al. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci U S A. 2008;105:11915–11920. 36. Cartegni L, Chew SL, Krainer AR. Listening to silence and understanding nonsense: exonic mutations that affect splicing. Nat Rev Genet.

Abraham et al. 1007/978-1-84882-637-3_2, © Springer-Verlag London Limited 2010 25 26 NOS NPC PDGFR SERCA2a SHR SMC TIMPs VEGF R. Masson et al. 1 Gene Therapy Advancement in the understanding of molecular therapeutics has allowed the development of novel treatments to prevent and treat many diseases. Originally conceived for the treatment of inherited monogenic disorders, such as Duchenne’s muscular dystrophy and hemophilia, where gene replacement should restore a normal phenotype, gene therapy approaches can now be applied to the treatment of more complex acquired diseases, including cardiovascular diseases (CVDs) and cancers.

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Advances in Vascular Medicine by Ioannis Papaioannou, James S. Owen (auth.), David Abraham, Handler Clive, Michael Dashwood, Gerry Coghlan (eds.)


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